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Bulk RNA Sequencing of Wild Type and Cisplatin Induced AKI (3d and 7d groups) Mice Kidneys

GSE220674 Mus musculus (mouse) RNA-seq (gene expression) 11 samples Submitted 2025/08/21 Platform GPL21103
At a glance

RNA-seq (gene expression) · mouse · 11 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
11 samples: 4 × Cis3d Group vs 4 × Cis7d Group vs 3 × Sham GroupGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Single-cell RNA sequencing reveals the protective role of renal Cx3cr1(+) macrophages in cisplatin-induced acute kidney injuryThe FEBS journal · 2026
Summary (written by the submitters)
To investigate the gene expression transition of injury pattern (progression stage) to repair pattern (regression stage) from 3 days to 7 days after acute injury of kidney tissue.
Published in
Single-cell RNA sequencing reveals the protective role of renal Cx3cr1(+) macrophages in cisplatin-induced acute kidney injury
Deng B, Ma M, Deng W et al. · The FEBS journal 2026 · PMID 41147753 · doi:10.1111/febs.70302
This dataset
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE220674_RAW.tar (it can run to tens of gigabytes).

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA910959 and SRA study SRP412418. Searching any of these in the dataset finder brings you back here.

Study design
4 × Cis3d Group vs 4 × Cis7d Group vs 3 × Sham Group

Supports a between-group comparison across 11 samples.

How we read this: 3 replicated groups read from 11 sample titles; they account for 11 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.