← BioTransfer GEO Dataset Finder
GEO series

Transcriptional profiling of embryos lacking Flvcr1

GSE221231 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/06/27 Platform GPL21103
Summary
Flvcr1 is a heme transporter involved in multiple processes. Here we invetigated the role of this transporter in brain development in mice. Deletion of Flvcr1 in nerual progenitors leads to metabolic collapse of neural progenitors and cortical disruption. Using transcriptional profiling, we show that brains of these embryos expressed reduced levels of electron transport chain components and increased levels of heme metabolic genes. These results implicate Flvcr1 in brain development through control of the metabolic state in neural progenitors.
Published in
Dysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus
Bertino F, Mukherjee D, Bonora M et al. · Cell reports. Medicine 2024 · PMID 39019006 · doi:10.1016/j.xcrm.2024.101647
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE221231_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA913440 and SRA study SRP413571. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.