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Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and Wac B Cell Conditional Knockout Activated B Cells Transcriptomes

GSE221490 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/12/04 Platform GPL13112
Summary
To investigate the function of Wac in the regulation of B cell activation and plasmablasts differentiation, we used Cre-Loxp system to generate Wac conditional knockout mice (Wacf/f Cd19cre/+). We then performed gene expression profiling analysis using data obtained from RNA-seq of in vitro LPS activated wild-type and Wac knockout B cells.
Published in
The histone H2B ubiquitination regulator Wac is essential for plasma cell differentiation
Li Y, Ruan GX, Chen W et al. · FEBS letters 2023 · PMID 37171241 · doi:10.1002/1873-3468.14633
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Also filed as BioProject PRJNA914675 and SRA study SRP414268. Searching any of these in the dataset finder brings you back here.

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