GEO series
BDNF-TrkB signalling depletion from the indirect pathway spiny projection neurons (iSPN) leads to age-dependent spontaneous hyperlocomotion.
GSE221922
Mus musculus
Expression profiling by high throughput sequencing
40 samples
2024/09/05
GPL17021
Summary
Therefore, we have established a unique mouse model that provides a rare example of an age-dependent locomotor defect to identify the genes and associated molecular pathways relevant to maintaining locomotor control. Thus, we performed gene expression profiling analysis using data from RNA-seq of 2 different striatal populations at two time points in the presence and absence of the TrkB signalling.
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Paper (PMID 39468205) ↗
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