BDNF-TrkB signalling depletion from the indirect pathway spiny projection neurons (iSPN) leads to age-dependent spontaneous hyperlocomotion.
RNA-seq (gene expression) · mouse · 40 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 40 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Impaired striatal glutathione-ascorbate metabolism induces transient dopamine increase and motor dysfunctionNature metabolism · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE221922_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA916738. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 40 more — browse all 40 samples with per-sample file links →
- GSE316516 Projection-defined amygdala neurons encode emotional memory through distinct transcriptomic programs 15 samples shares projection, neurons
- GSE276009 Comparative Single Cell Transcriptome Analysis of c-Met Receptor Expressing and Non-Expressing Projection Neurons in the Developing Frontal and Visual Cortices 12 samples shares projection, neurons
- GSE314177 Postnatal day 3 (P3) mouse cortical projection neurons: Ctrl versus Cdk7 KO 10 samples shares projection, neurons
- GSE198214 Gene changes associated with deletion of Esrrg in spiny projection neurons in mice using RNA sequencing 6 samples shares projection, neurons
- GSE283035 Satb2 gene dosage in cortical projection neurons impacts neuronal maturation and somatosensory processing 47 samples shares projection, neurons
- GSE283033 Satb2 gene dosage in cortical projection neurons impacts neuronal maturation and somatosensory processing [CUT&RUN] 39 samples shares projection, neurons
- GSE277718 Projection-TAGs enable multiplex projection tracing and multi-modal profiling of projection neurons 20 samples shares projection, neurons
- GSE2039 FACS purified cortical projection neurons 19 samples shares projection, neurons
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.