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DOT1L controls NK cell maturation and lineage integrity

GSE222235 Mus musculus (mouse) ChIP-seq / ATAC-seq (genome binding and open chromatin) 27 samples Submitted 2024/04/30 Platform GPL30215Platform GPL19057
At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 27 samples

What it is
ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism
Mus musculus (mouse)
Samples
27 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
DOT1L maintains NK cell phenotype and function for optimal tumor controlCell reports · 2024
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
Published in
DOT1L maintains NK cell phenotype and function for optimal tumor control
Sudholz H, Schuster IS, Foroutan M et al. · Cell reports 2024 · PMID 38865244 · doi:10.1016/j.celrep.2024.114333
This dataset
Open GSE222235 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE222235_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA918648 and SRA study SRP415998. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 38865244) ↗
Study design
6 conditions, mostly in triplicate
splenic sorted NK cells, wild type, ×3 splenic sorted NK cells, knockout, ×3 splenic sorted NK cells, knockout, d2 MCMV, ×3 NK cell, cultured, d5, wild type, ×3 NK cell, cultured, d5, knockout, ×3 splenic sorted NK cells, wild type, d2 MCMV, ×2 WT input ×1 WT H3K4me ×1 +8 more

Supports a case/control comparison: 9 samples read as cases, 11 as controls.

How we read this: 6 replicated groups read from 27 sample titles; they account for 17 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

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