ChIP-seq analysis of control and DOT1L HET cortical nuclei.
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 18 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 8 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Loss of DOT1L disrupts neuronal transcription and leads to a neurodevelopmental disorderBrain : a journal of neurology · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE292609_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1240293 and SRA study SRP572229. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 8 replicated groups read from 18 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8862381 Control_Female_H3K79me2_R1 Control_Female_H3K79me2
- GSM8862382 HET_Female_H3K79me2_R1 HET_Female_H3K79me2
- GSM8862383 Control_Female_H3K79me2_R2 Control_Female_H3K79me2
- GSM8862384 HET_Female_H3K79me2_R2 HET_Female_H3K79me2
- GSM8862385 Control_Male_H3K79me2_R3
- GSM8862386 HET_Male_H3K79me2_R3 HET_Male_H3K79me2
- GSM8862387 Control_Male)H3K79me2_R4
- GSM8862388 HET_Male_H3K79me2_R4 HET_Male_H3K79me2
- GSM8862389 Control_Female_input_R1 Control_Female_input
- GSM8862390 HET_Female_input_R1 HET_Female_input
- GSM8862391 Control_Female_input_R2 Control_Female_input
- GSM8862392 HET_Female_input_R2 HET_Female_input
- GSM8862393 Control_Male_input_R3 Control_Male_input
- GSM8862394 HET_Male_input_R3 HET_Male_input
- GSM8862395 Control_Male_input_R4 Control_Male_input
- GSM8862396 HET_Male_input_R4 HET_Male_input
- GSM8862397 IgG_control_R1 IgG_control
- GSM8862398 IgG_control_R2 IgG_control
- GSE264193 H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos [ChIP-seq] 57 samples shares het, chip-seq
- GSE305266 The cortical microenvironment drives early immune organization and controls early osteoclastogenesis in bone healing 90 samples shares cortical, control
- GSE274875 A mutant ASXL1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia [Cut & Run] 38 samples shares het
- GSE233039 The H3K9me3 heterochromatin integrity and function are sustained by H3K9me3 methyltransferases-HP1 dependencies [ATAC-Seq] 18 samples shares het
- GSE294832 Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part10] 1000 samples shares het
- GSE294911 Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part14] 1000 samples shares het
- GSE294535 Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice[part5] 1000 samples shares het
- GSE294849 Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part13] 1000 samples shares het
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.