Effect of olanzapine and aripiprazole supplemented diet treatments on gene expression of WT and PTP1B KO mice liver
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 6 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE222697_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA923038 and SRA study SRP417092. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 6 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6929141 WT, Aripiprazole, biol rep 1 WT, Aripiprazole, biol
- GSM6929142 WT, Aripiprazole, biol rep 2 WT, Aripiprazole, biol
- GSM6929143 WT, Olanzapine, biol rep 1 WT, Olanzapine, biol
- GSM6929144 WT, Olanzapine, biol rep 2 WT, Olanzapine, biol
- GSM6929145 WT, Control, biol rep 1 WT, Control, biol
- GSM6929146 WT, Control, biol rep 2 WT, Control, biol
- GSM6929147 PTP1B KO, Aripiprazole, biol rep 1 PTP1B KO, Aripiprazole,…
- GSM6929148 PTP1B KO, Aripiprazole, biol rep 2 PTP1B KO, Aripiprazole,…
- GSM6929149 PTP1B KO, Olanzapine, biol rep 1 PTP1B KO, Olanzapine, b…
- GSM6929150 PTP1B KO, Olanzapine, biol rep 2 PTP1B KO, Olanzapine, b…
- GSM6929151 PTP1B KO, Control, biol rep 1 PTP1B KO, Control, biol
- GSM6929152 PTP1B KO, Control, biol rep 2 PTP1B KO, Control, biol
- GSE271279 Identification of the role of PTP1B in acute kidney injury and its regulation via siRNA delivery with milk-derived extracellular vesicles 9 samples shares ptp1b, liver
- GSE315007 Sex- and hepatocyte Pparg-dependent hepatic effects of a high fat diet containing 60% kcal from fat and 2% cholesterol, which was supplemented with 10% fructose in the drinking water (HFC+Fr) to induce diet-induced obesity in male and female mice. 30 samples shares supplemented, diet
- GSE297351 Methionine-supplemented Longevity diet increases GLP-1 and FGF21 to reduce frailty and promote healthspan 10 samples shares supplemented, diet
- GSE293050 RNA-seq results in the liver of male hepatocyte-specific GAPDH knockout mice in fasting supplemented with or without serine 6 samples shares supplemented, liver
- GSE223828 Loss of the O-GlcNAcylation in Hepatic Differentiation utilizing choline-deficient ethionine supplemented diet 4 samples shares supplemented, diet
- GSE283503 Ptp1b inhibition improves the macrophage anti-tumor immune response and the efficacy of chemo- and radiotherapy. 16 samples shares ptp1b
- GSE247265 Burdock miR8175 improves insulin sensitivity in DIO mice by targeting PTP1B and PTPRF [I] 6 samples shares ptp1b
- GSE315736 PTP1B inhibition promotes microglial phagocytosis in Alzheimer's disease models by enhancing SYK signaling 4 samples shares ptp1b
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.