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Loss of the O-GlcNAcylation in Hepatic Differentiation utilizing choline-deficient ethionine supplemented diet

GSE223828 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/01/25 Platform GPL24247
Summary
We studied the effects of loss of hepatic O-GlcNAc Transferase (OGT), the enzyme that attaches the O-GlcNAc to protein, in a choline-deficient and ethionine (CDE) supplemented model. We placed hepatocyte-specific OGT knockout mice (OGT-KO) and controls on the CDE diet for 2 weeks. We then performed RNA sequencing. We then repeated the 2-week CDE diet with the addition of a 7-day normal diet recovery period. We then performed RNA-Sequencing on isolated RNA from whole liver lysate to determine differentially expressed genes.
Published in
The essential role of O-GlcNAcylation in hepatic differentiation
Robarts DR, Kotulkar M, Paine-Cabrera D et al. · Hepatology communications 2023 · PMID 37930118 · doi:10.1097/HC9.0000000000000283
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Also filed as BioProject PRJNA928478 and SRA study SRP419314. Searching any of these in the dataset finder brings you back here.

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