Endomucin marks quiescent long-term multi-lineage repopulating hematopoietic stem cells and is essential for their transendothelial migration [RNA-seq: wildtype_EMCN]
RNA-seq (gene expression) · mouse · 11 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 11 samples: 4 × LTHSC_EMCNplus vs 4 × GMP vs 3 × LTHSC_EMCNminusGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Endomucin marks quiescent long-term multi-lineage repopulating hematopoietic stem cells and is essential for their transendothelial migrationCell reports · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE222941_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA924266 and SRA study SRP417703. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 11 samples.
How we read this: 3 replicated groups read from 11 sample titles; they account for 11 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6935628 LTHSC_EMCNplus_1 LTHSC_EMCNplus
- GSM6935629 LTHSC_EMCNminus_1 LTHSC_EMCNminus
- GSM6935630 GMP_1 GMP
- GSM6935631 LTHSC_EMCNplus_2 LTHSC_EMCNplus
- GSM6935632 LTHSC_EMCNminus_2 LTHSC_EMCNminus
- GSM6935633 GMP_2 GMP
- GSM6935634 LTHSC_EMCNplus_3 LTHSC_EMCNplus
- GSM6935635 GMP_3 GMP
- GSM6935636 LTHSC_EMCNplus_4 LTHSC_EMCNplus
- GSM6935637 LTHSC_EMCNminus_4 LTHSC_EMCNminus
- GSM6935638 GMP_4 GMP
- GSE274033 RNA-seq of sorted murine long-term hematopoietic stem cells segmented on CUX1 levels with and without CUX1 knockdown 35 samples shares hematopoietic, long-term
- GSE338821 RNA profiles of hematopoietic stem cells before and after long-term culture [RNA-Seq] 24 samples shares hematopoietic, long-term
- GSE230834 Impaired repopulating ability of Uhrf2-/- hematopoietic progenitor cells in mice. 12 samples shares hematopoietic, repopulating
- GSE274544 Single cell profiling reveals three endothelial to hematopoietic transitions with divergent isoform expression landscapes [scRNA-Seq] 1494 samples shares hematopoietic
- GSE265909 yHSC and oHSC scRNAseq with oHSC AThi ATlo Index Sorting. Assessing the transcriptional changes associated with autophagy engagement in old hematopoietic stem cells at single cell resolution. [scRNA-Seq] 563 samples shares hematopoietic
- GSE309071 Single cell profiling reveals three endothelial to hematopoietic transitions with divergent isoform expression landscapes [RNA-seq] 221 samples shares hematopoietic
- GSE165881 Establishment of hematopoietic stem cell compartment after single cell transplantation tracked by FIT approach 62 samples shares hematopoietic
- GSE266509 A Bcl11a-driven mechanism maintaining hematopoietic stem cell functionality gives rise to dysfunction during aging [RNA-Seq] 52 samples shares hematopoietic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.