Impaired repopulating ability of Uhrf2-/- hematopoietic progenitor cells in mice.
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 5 × Uhrf2 KO LSK vs 5 × Uhrf2 WT LSKGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE230834_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA962800 and SRA study SRP434978. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 10 samples.
How we read this: 2 replicated groups read from 12 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7221789 Uhrf2 KO LSK 1 Uhrf2 KO LSK
- GSM7221790 Uhrf2 KO LSK 2 Uhrf2 KO LSK
- GSM7221791 Uhrf2 KO LSK 3 Uhrf2 KO LSK
- GSM7221792 Uhrf2 KO LSK 4 Uhrf2 KO LSK
- GSM7221793 Uhrf2 KO LSK 5 Uhrf2 KO LSK
- GSM7221794 Uhrf2 WT LSK 1 Uhrf2 WT LSK
- GSM7221795 Uhrf2 WT LSK 2 Uhrf2 WT LSK
- GSM7221796 Uhrf2 WT LSK 3 Uhrf2 WT LSK
- GSM7221797 Uhrf2 WT LSK 4 Uhrf2 WT LSK
- GSM7221798 Uhrf2 WT LSK 5 Uhrf2 WT LSK
- GSM7244855 Uhrf2 KO
- GSM7244856 WT
- GSE268058 PPARγ-dependent Remodeling of Translational Machinery in Adipose Progenitors is Impaired in Obesity 24 samples shares progenitor, impaired
- GSE272588 Multipotent progenitors with distinct origins, clonal lineage fates, transcriptomes, and surface markers yield two hematopoietic trees 605 samples shares hematopoietic, progenitor
- GSE278208 STING Mediates Increased Self-Renewal and Lineage Skewing in DNMT3A-Mutated Hematopoietic Stem/Progenitor Cells 40 samples shares hematopoietic, progenitor
- GSE308698 Impaired IL-10 Receptor Signaling Leads to Inflammation Induced Exhaustion in Hematopoietic Stem Cells 17 samples shares hematopoietic, impaired
- GSE224160 Malaria pigment hemozoin-induced chromatin remodeling of mouse hematopoietic stem and progenitor cells, granulocyte-macrophage progenitors, and bone marrow monocytes 12 samples shares hematopoietic, progenitor
- GSE294951 GABA produced by multiple bone marrow niche cell types regulate hematopoietic stem and progenitor cells 12 samples shares hematopoietic, progenitor
- GSE222941 Endomucin marks quiescent long-term multi-lineage repopulating hematopoietic stem cells and is essential for their transendothelial migration [RNA-seq: wildtype_EMCN] 11 samples shares hematopoietic, repopulating
- GSE276137 The ac4C acetyltransferase Nat10 promotes RNA stability to support hematopoietic stem cell fate [RNA-seq-32D] 24 samples shares hematopoietic, ability
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.