ChREBPα protects against diet-induced non-alcoholic fatty liver disease
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 16 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Suppression of hepatic ChREBP⍺-CYP2C50 axis-driven fatty acid oxidation sensitizes mice to diet-induced MASLD/MASHMolecular metabolism · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE223649_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA927023 and SRA study SRP418922. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 16 sample titles: 16 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6969950 9_HFLMCD_Ad-GFP
- GSM6969951 10_HFLMCD_Ad-GFP
- GSM6969952 11_HFLMCD_Ad-GFP
- GSM6969953 12_HFLMCD_Ad-GFP
- GSM6969954 13_HFLMCD_Ad-Chrebp_alpha
- GSM6969955 14_HFLMCD_Ad-Chrebp_alpha
- GSM6969956 15_HFLMCD_Ad-Chrebp_alpha
- GSM6969957 16_HFLMCD_Ad-Chrebp_alpha
- GSM6969958 17_NASH_Chrebp_alpha-WT
- GSM6969959 18_NASH_Chrebp_alpha-WT
- GSM6969960 19_NASH_Chrebp_alpha-WT
- GSM6969961 20_NASH_Chrebp_alpha-WT
- GSM6969962 21_NASH_Chrebp_alpha-LKO
- GSM6969963 22_NASH_Chrebp_alpha-LKO
- GSM6969964 23_NASH_Chrebp_alpha-LKO
- GSM6969965 24_NASH_Chrebp_alpha-LKO
- GSE294945 Mechanistic basis for protection against fatty liver disease by CIDEB loss-of-function mutations 20 samples shares against, fatty, liver
- GSE338380 Hepatocyte angiotensinogen deletion protects against Western diet-induced adiposity and hepatic steatosis under thermoneutral housing 48 samples shares diet-induced, protects, against
- GSE312061 Liver-specific delivery of MDM2 antisense oligonucleotides counteracts diet-induced metabolic dysfunction-associated steatotic liver diseases 18 samples shares diet-induced, liver
- GSE278384 Colonic Epithelial-derived FGF1 Protects against Inflammatory Bowel Disease via Driving Intestinal Stem Cells Differentiation toward Goblet Cells 12 samples shares protects, against
- GSE296768 Plaque-induced transcriptional reprogramming of microglia towards lymphoid receptor expression protects against Alzheimer's disease [scRNA-seq] 12 samples shares protects, against
- GSE262523 Diet-Induced Obesity Disrupts Sexually Dimorphic Gene Expression in Liver and Adipose Tissue in Mice 48 samples shares diet-induced, liver
- GSE292568 Arachidonoyl-taurine protects from diet-induced hepatic steatosis and inflammation 32 samples shares diet-induced, protects
- GSE289432 Y665F variant of mouse STAT5b protects against acute kidney injury through transcriptomic shifts in renal gene expression 32 samples shares protects, against
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.