GEO series
Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia
GSE224816
Homo sapiens; Mus musculus
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
22 samples
2024/04/23
GPL24247GPL24676
Summary
Here we report a new fusion gene, STRN3-RARA, in acute promyelocytic leukemia (APL). It cooperates with UTX deficiency to drive full-blown APL in mice. Although STRN3-RARA leukemia quickly relapses after all-trans retinoic acid treatment, it can be restrained by cepharanthine.
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Paper (PMID 37624915) ↗
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