Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis [Prox1 OE iHep Timecourse scRNA-seq]
Single-cell RNA-seq · mouse · 13 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart.
- Organism
- Mus musculus (mouse)
- Samples
- 13 samples: 13 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesisNature genetics · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE224830_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA934512 and SRA study SRP424215. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 13 sample titles: 13 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7033723 MEF 4in1_GFP_OE day02 [scRNA-seq]
- GSM7033724 MEF 4in1_Prox1_OE day02 [scRNA-seq]
- GSM7033725 MEF 4in1_OE day02 barcodes [scRNA-seq]
- GSM7033726 MEF 4in1_GFP_OE day07 [scRNA-seq]
- GSM7033727 MEF 4in1_Prox1_OE day07 [scRNA-seq]
- GSM7033728 MEF 4in1_OE day07 barcodes [scRNA-seq]
- GSM7033729 MEF 4in1_GFP_OE day14 [scRNA-seq]
- GSM7033730 MEF 4in1_Prox1_OE day14 [scRNA-seq]
- GSM7033731 MEF 4in1_OE day14 barcodes [scRNA-seq]
- GSM7033732 MEF unreprogrammed day02 [scRNA-seq]
- GSM7033733 MEF Myod1_OE day02 [scRNA-seq]
- GSM7033734 MEF unreprogrammed_or_Myod1_OE barcodes [scRNA-seq]
- GSM7033735 MEF all remaining barcodes [scRNA-seq]
- GSE280084 A Multipotent PROX1+ Tumor Cell Population Emerges During Intestinal Tumorigenesis and Mediates Radioresistance in Colorectal Cancer 13 samples shares prox1, tumorigenesis
- GSE280835 Divergent FOXA1 mutations drive prostate tumorigenesis or therapy-resistant intra-luminal plasticity [RNA-Seq] 38 samples shares tumorigenesis, plasticity
- GSE263415 Spatial hepatocyte plasticity of gluconeogenic gene expression and gluconeogenic activity during the metabolic transitions between fed, fasted and starvation states [RNA-Seq] 18 samples shares plasticity, hepatocyte
- GSE277228 Changing dynamics of the fibroblast differentiation hierarchy during mammary gland morphogenesis and tumorigenesis [scRNA-Seq I] 13 samples shares tumorigenesis, scrna-seq
- GSE299487 LY6D Identifies Persistent Tumor-Initiating Cells Driving Pancreatic Tumorigenesis [scRNA-seq] 12 samples shares tumorigenesis, scrna-seq
- GSE269507 The interleukin 22–oncostatin M axis promotes intestinal inflammation and tumorigenesis [scRNA-seq] 12 samples shares tumorigenesis, scrna-seq
- GSE270727 Analysis of striatal zinc finger protein (ZFP) repression of mutant Huntingtin (HTT) in the zQ175DN knock-in mouse model of Huntington's disease (bulk RNA-seq) 233 samples shares repression
- GSE300428 Rbm24 promotes outer hair cell survival through Insm1 repression while independently regulating hair bundle morphogenesis 163 samples shares repression
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.