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Hypoxia induces transcriptomic changes in bone marrow cells leading to increased erythropoiesis [TFPI]

GSE224993 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/03/01 Platform GPL24247
Summary
Erythropoiesis takes place mostly in bone marrow and ends in blood. Previous studies have shown that hypoxia has direct effects on the bone marrow, which could promotes erythropoiesis by modulating erythroid progenitor maturation. However, how bone marrow microenvironment participates in erythropoiesis under hypoxia still need further clarification. In this study, we analyzed transcriptional changes of bone marrow cells of mice exposed to 5000 m altitude hypoxia for 1 week. We profiled the top 20 up-regulated secreted factor genes after treatment with hypoxia, and found TFPI was one of the secreted factor genes with the highest expression.
Published in
TFPI from erythroblasts drives heme production in central macrophages promoting erythropoiesis in polycythemia
Ma JK, Su LD, Feng LL et al. · Nature communications 2024 · PMID 38729948 · doi:10.1038/s41467-024-48328-8
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Also filed as BioProject PRJNA933339 and SRA study SRP421762. Searching any of these in the dataset finder brings you back here.

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