Intermittent Hypoxia Induces Cognitive Dysfunction and Hippocampal Gene Expression Changes in a Mouse Model of Obstructive Sleep Apnea
RNA-seq (gene expression) · mouse · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 14 samples: 5 × Hippocampus, IH group (oxygen alternating between 10-21% in 2-minute cycles, 8 hours/day), vs 5 × Hippocampus, sustained hypoxia group (SH) (10% oxygen, 8 hours/day), vs 4 × Hippocampus, control group (21% oxygen, 28 days),Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Intermittent Hypoxia Induces Cognitive Dysfunction and Hippocampal Gene Expression Changes in a Mouse Model of Obstructive Sleep ApneaInternational journal of molecular sciences · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE299437_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1274422 and SRA study SRP591055. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 14 samples.
How we read this: 3 replicated groups read from 14 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9039219 Hippocampus, control group (21% oxygen, 28 days), rep1 Hippocampus, control gr…
- GSM9039220 Hippocampus, control group (21% oxygen, 28 days), rep2 Hippocampus, control gr…
- GSM9039221 Hippocampus, control group (21% oxygen, 28 days), rep3 Hippocampus, control gr…
- GSM9039222 Hippocampus, control group (21% oxygen, 28 days), rep4 Hippocampus, control gr…
- GSM9039223 Hippocampus, IH group (oxygen alternating between 10-21% in 2-minute cycles, 8 hours/day), rep1 Hippocampus, IH group …
- GSM9039224 Hippocampus, IH group (oxygen alternating between 10-21% in 2-minute cycles, 8 hours/day), rep2 Hippocampus, IH group …
- GSM9039225 Hippocampus, IH group (oxygen alternating between 10-21% in 2-minute cycles, 8 hours/day), rep3 Hippocampus, IH group …
- GSM9039226 Hippocampus, IH group (oxygen alternating between 10-21% in 2-minute cycles, 8 hours/day), rep4 Hippocampus, IH group …
- GSM9039227 Hippocampus, IH group (oxygen alternating between 10-21% in 2-minute cycles, 8 hours/day), rep5 Hippocampus, IH group …
- GSM9039228 Hippocampus, sustained hypoxia group (SH) (10% oxygen, 8 hours/day), rep1 Hippocampus, sustained…
- GSM9039229 Hippocampus, sustained hypoxia group (SH) (10% oxygen, 8 hours/day), rep2 Hippocampus, sustained…
- GSM9039231 Hippocampus, sustained hypoxia group (SH) (10% oxygen, 8 hours/day), rep3 Hippocampus, sustained…
- GSM9039233 Hippocampus, sustained hypoxia group (SH) (10% oxygen, 8 hours/day), rep4 Hippocampus, sustained…
- GSM9039235 Hippocampus, sustained hypoxia group (SH) (10% oxygen, 8 hours/day), rep5 Hippocampus, sustained…
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.