← BioTransfer GEO Dataset Finder
GEO series

Control of Embryonic Stem Cell State by Mediator and Cohesin (Illumina ChIP-Seq data)

GSE22562 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 17 samples Submitted 2010/08/12 Platform GPL9250
Summary
The key transcription factors that control the embryonic stem cell gene expression program have been identified, but how they function to implement this program is not well understood. While screening for genes essential for maintenance of ES cell state, we identified many components of the Mediator and Cohesin complexes. Mediator and Cohesin were found to physically and functionally connect the enhancers and core promoters of active genes. An ES cell Mediator complex was found to copurify with Cohesin and its loading factor Nipbl, and normal levels of these proteins were essential for expression of the genes they occupy and for maintenance of ES cell state.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE22562_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 17 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA129097 and SRA study SRP002778. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 17 more — browse all 17 samples with per-sample file links →

Similar datasets

Search all mouse ChIP / ATAC / CUT&Tag datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.