GEO series
Single cell transcriptomic analyses of the dynamic local and systemic response to cardiac injury in mice and zebrafish [mouse]
GSE227189
Mus musculus
Expression profiling by high throughput sequencing
28 samples
2024/11/07
GPL24247
Summary
Mice respond to myocardial infarction (MI) by generating a fibrotic scar in the heart. This is accompanied by systemic inflammation after the MI resolves. In contrast, zebrafish can fully regenerate their heart after heart injury. To further investigate the divergent species’ responses to cardiac injury, single cell transcriptomic analyses were performed on the heart, blood, liver, kidney, and pancreatic islets.
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Paper (PMID 39627536) ↗
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