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Gene expression profiles of sorted D1- and D2-expressing cells in mouse ventral hippocampus

GSE227313 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/12/01 Platform GPL24247
Summary
The hippocampus, as well as dopamine circuits, coordinate decision-making in anxiety-eliciting situations. Yet, little is known about how dopamine modulates hippocampal representations of emotionally-salient stimuli to inform appropriate resolution of approach versus avoidance conflicts. We here study dopaminoceptive neurons in mouse ventral hippocampus (vHipp), molecularly distinguished by their expression of dopamine D1 or D2 receptors. We show that these neurons are transcriptionally distinct and topographically organized across vHipp subfields and cell types. While both D1 and D2 vHipp neurons are recruited during anxiogenic exploration, they mediate opposite approach/avoidance responses, and are differentially modulated by dopaminergic transmission. We propose that vHipp dopamine dynamics operate as a feedback loop to gate exploratory behaviors, implicating dopaminoception in the complex computation engaged in vHipp to govern emotional states.
Published in
Dopaminoceptive D1 and D2 neurons in ventral hippocampus arbitrate approach and avoidance in anxiety
Godino A, Salery M, Minier-Toribio AM et al. · bioRxiv : the preprint server for biology 2023 · PMID 37546856 · doi:10.1101/2023.07.25.550554
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Also filed as BioProject PRJNA944631 and SRA study SRP427257. Searching any of these in the dataset finder brings you back here.

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