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Base barrier cells provide compartmentalization of choroid plexus, brain and CSF

GSE227969 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/08/21 Platform GPL21103
Summary
The choroid plexus (ChP), located in the brain ventricles, is largely composed of ChP epithelial cells that produce the cerebrospinal fluid (CSF) and form the blood–CSF barrier. At the ChP–brain attachment sites, we have discovered unique fibroblasts referred to as ChP base barrier cells (BBCs). We show that ChP BBCs originate from meningeal mesenchymal precursors, arrive early during development, remain throughout life and are conserved across species. ChP BBCs are transcriptionally similar to meningeal arachnoid barrier cells and are interconnected by both adherens and tight junctions. Notably, we provide evidence that the BBCs function as a barrier, controlling communication between the periphery and central nervous system. Moreover, during inflammatory insult, we observed a loss of barrier integrity and immune cell crossing. Altogether, our research revealed a barrier at the ChP base, crucial in protecting the central nervous system by compartmentalizing the ChP stroma, brain parenchyma and CSF.
Published in
Base barrier cells provide compartmentalization of choroid plexus, brain and CSF
Verhaege D, De Nolf C, Van Acker L et al. · Nature neuroscience 2026 · PMID 41680326 · doi:10.1038/s41593-025-02188-7
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Direct links to NCBI, no account and no request form: the whole study as GSE227969_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗ Raw reads on ENA ↗

Also filed as BioProject PRJNA947590 and SRA study SRP428664. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41680326) ↗
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