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ALK upregulates POSTN and WNT signaling to drive neuroblastoma

GSE228194 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/03/21 Platform GPL24676
Summary
The goal of this study is to identify the mechanism for how ALK promotes tumorigenesis in neuroblastoma. We developed a human stem cell model of neuroblastoma and generated isogenic tumors using MYCN and MYCN/ALK. RNAseq analysis of both tumors revealed an enrichment in focal adhesion signaling and allowed us to find POSTN as a key mediator of ALK-mediated tumor growth.
Published in
ALK upregulates POSTN and WNT signaling to drive neuroblastoma
Huang M, Fang W, Farrel A et al. · Cell reports 2024 · PMID 38451815 · doi:10.1016/j.celrep.2024.113927
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Also filed as BioProject PRJNA948479 and SRA study SRP429164. Searching any of these in the dataset finder brings you back here.

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