GEO series
The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma
GSE229150
Homo sapiens
Expression profiling by high throughput sequencing
30 samples
2025/03/28
GPL24676
Summary
In this study, we investigate the potential role of BMP stimulation on the oncogenic capacity of Medulloblastoma cells. BMP7 stimulation demonstrated pleiotropic effects on the investigated cells, inducing high cancer stem cell capacity or cell death. In addition, we uncovered the role of LHX2 as a prominent target of BMP7 signaling that can alter the stem cell capacity and positively modulate BMP signaling through a forward feedback loop.
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Paper (PMID 40148468) ↗
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