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Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis resistance in Breast Cancer

GSE229792 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2024/07/23 Platform GPL24676
Summary
Here, we discovered that CoQ10 and its biosynthetic enzyme UBIAD1 play a critical role in plasma membrane mechanical properties that are of interest for breast cancer (BC) progression and treatment. In detail, CoQ10 and UBIAD1 increased membrane fluidity leading to increased cell stiffness in BC. High UBIAD1/CoQ10 states impair lipid rafts and ECM-mediated oncogenic signaling and reduce the ferroptosis resistance of BC cells. Furthermore, analyses on BC patients and BC mouse models reveal that UBIAD1 loss is associated with BC development and progression. UBIAD1 expression in aggressive BC limits CTCs survival and lung metastasis formation in experimental xenograft assays.
Published in
Cancer cell stiffening via CoQ(10) and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer
Tosi G, Paoli A, Zuccolotto G et al. · Nature communications 2024 · PMID 39294175 · doi:10.1038/s41467-024-52523-y
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Also filed as BioProject PRJNA955830. Searching any of these in the dataset finder brings you back here.

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