ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 51 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- Prostate cancerThis series is part of our curated briefing on it.
- Samples
- 51 samples: 13 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate CancerCancer discovery · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE230602_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA961830 and SRA study SRP434479. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 30 samples.
How we read this: 13 replicated groups read from 51 sample titles; they account for 30 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7229663 Ctrl, Androgen Receptor, Abcam
- GSM7229664 Ctrl, Input
- GSM7229665 KD, Androgen Receptor, Abcam
- GSM7229666 KD, Input
- GSM7229667 gNT_Veh [CtrlFS1]
- GSM7229668 gNT_Veh [CtrlFS2]
- GSM7229669 gNT_Veh [CtrlFS3]
- GSM7229670 gZNF397_Veh [KOFS1]
- GSM7229671 gZNF397_Veh [KOFS2]
- GSM7229672 gZNF397_Veh [KOFS3]
- GSM7229673 gNT_Enz [CtrlCE1]
- GSM7229674 gNT_Enz [CtrlCE2]
- GSM7229675 gNT_Enz [CtrlCE3]
- GSM7229676 gZNF397_Enz [KOCE1]
- GSM7229677 gZNF397_Enz [KOCE2]
- GSM7229678 gZNF397_Enz [KOCE3]
- GSM8117788 GFP_ZNF397_input_1 GFP_ZNF397_input
- GSM8117789 GFP_ZNF397_input_2 GFP_ZNF397_input
- GSM8117790 GFP_ZNF397_ChIPed_1 GFP_ZNF397_ChIPed
- GSM8117791 GFP_ZNF397_ChIPed_2 GFP_ZNF397_ChIPed
- GSM8117792 sgNT_H3K27ac_1 sgNT_H3K27ac
- GSM8117793 sgNT_H3K27ac_2 sgNT_H3K27ac
- GSM8117794 sgZNF397_H3K27ac_1 sgZNF397_H3K27ac
- GSM8117795 sgZNF397_H3K27ac_2 sgZNF397_H3K27ac
- GSM8117796 sgNTInput
- GSM8117797 sgZNF397Input
- GSM8117798 sgNT_H3K4me3_1 sgNT_H3K4me3
- GSM8117799 sgNT_H3K4me3_2 sgNT_H3K4me3
- GSM8117800 sgZNF397_H3K4me3_1 sgZNF397_H3K4me3
- GSM8117801 sgZNF397_H3K4me3_2 sgZNF397_H3K4me3
- GSM8117802 sgNT_5hmC_input
- GSM8117803 sgNT_5hmC_ChIPed_1 sgNT_5hmC_ChIPed
- GSM8117804 sgNT_5hmC_ChIPed_2 sgNT_5hmC_ChIPed
- GSM8117805 sgZNF397_5hmC_input
- GSM8117806 sgZNF397_5hmC_ChIPed_1 sgZNF397_5hmC_ChIPed
- GSM8117807 sgZNF397_5hmC_ChIPed_2 sgZNF397_5hmC_ChIPed
- GSM8117808 sgZNF397_sgTET2_5hmC_input
- GSM8117809 sgZNF397_sgTET2_5hmC_ChIPed_1 sgZNF397_sgTET2_5hmC_Ch…
- GSM8117810 sgZNF397_sgTET2_5hmC_ChIPed_2 sgZNF397_sgTET2_5hmC_Ch…
- GSM8117811 sgNT-1 sgNT
+ 11 more — browse all 51 samples with per-sample file links →
- GSE115501 RNA sequencing on circulating tumor cells from prostate cancer patients 136 samples same disease briefing · shares prostate
- GSE222467 The RNA binding proteins LARP4A and LARP4B promote tumour growth and metastasis in prostate cancer and osteosarcoma 12 samples same disease briefing · shares prostate
- GSE242541 ONECUT2 is a druggable driver of luminal to basal breast cancer plasticity 12 samples same disease briefing · shares plasticity
- GSE300947 A novel six-biomarker panel identified from male breast cancer-associated fibroblasts demonstrates prognostic power for prostate tumors 6 samples same disease briefing · shares prostate
- GSE120181 Human prostate cancer cell line, 22Rv1: Control vs. luteolin treatment 2 samples same disease briefing · shares prostate
- GSE71008 Plasma extracellular RNA profiles in healthy and cancer patients 192 samples same disease briefing
- GSE230600 ZNF397 Deficiency Triggers TET2-driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer [ChIP-seq] 18 samples shares znf397, tet2-driven, ar-targeted, deficiency, plasticity, resistance, triggers, prostate
- GSE230601 ZNF397 Deficiency Triggers TET2-driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer [RNA-seq] 12 samples shares znf397, tet2-driven, ar-targeted, deficiency, plasticity, resistance, triggers, prostate
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.