ZNF397 Deficiency Triggers TET2-driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer [RNA-seq]
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate CancerCancer discovery · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE230601_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA961832 and SRA study SRP434479. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7229667 gNT_Veh [CtrlFS1]
- GSM7229668 gNT_Veh [CtrlFS2]
- GSM7229669 gNT_Veh [CtrlFS3]
- GSM7229670 gZNF397_Veh [KOFS1]
- GSM7229671 gZNF397_Veh [KOFS2]
- GSM7229672 gZNF397_Veh [KOFS3]
- GSM7229673 gNT_Enz [CtrlCE1]
- GSM7229674 gNT_Enz [CtrlCE2]
- GSM7229675 gNT_Enz [CtrlCE3]
- GSM7229676 gZNF397_Enz [KOCE1]
- GSM7229677 gZNF397_Enz [KOCE2]
- GSM7229678 gZNF397_Enz [KOCE3]
- GSE230602 ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer 51 samples shares znf397, tet2-driven, ar-targeted, deficiency, plasticity, resistance, triggers, prostate
- GSE230600 ZNF397 Deficiency Triggers TET2-driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer [ChIP-seq] 18 samples shares znf397, tet2-driven, ar-targeted, deficiency, plasticity, resistance, triggers, prostate
- GSE260467 ZNF397 Deficiency Triggers TET2-driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer [ATAC-seq] 12 samples shares znf397, tet2-driven, ar-targeted, deficiency, plasticity, resistance, triggers, prostate
- GSE310927 PRMT5 Inhibition Triggers Functional ATM Deficiency and Sensitizes Pancreatic Cancer to CHK1 Blockade 36 samples shares deficiency, triggers
- GSE247623 Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation 18 samples shares deficiency, resistance
- GSE269495 SNX10 deficiency confers resistance to anti-HER2 antibody-drug conjugates via regulating endosomal trafficking 13 samples shares deficiency, resistance
- GSE309028 TP53 deficiency in AML induces resistance to T-cell engagers through an immunosuppressive secretome 12 samples shares deficiency, resistance
- GSE309499 HDAC5 Deficiency Induces Intrinsic Resistance to KRASG12D Inhibition by Disrupting c-Myc Acetylation-Ubiquitination Homeostasis [RNA-seq] 12 samples shares deficiency, resistance
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.