A marker chromosome in psychosis identifies glycine decarboxylase (GLDC) as a novel negative regulator of excitatory synaptic activity in the hippocampus
RNA-seq (gene expression) · mouse · 64 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 64 samples: 64 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor functionMolecular psychiatry · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE230871_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA962890 and SRA study SRP435069. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 64 sample titles: 64 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7245946 t1979,cerebellum,dup-wt
- GSM7245947 T1979,cortex,dup-wt
- GSM7245948 t1979,striatum,dup-wt
- GSM7245949 t1980,cerebellum,dup-wt
- GSM7245950 T1980,cortex,dup-wt
- GSM7245951 t1980,striatum,dup-wt
- GSM7245952 t1981,cerebellum,dup-wt
- GSM7245953 T1981,cortex,dup-wt
- GSM7245954 t1981,striatum,dup-wt
- GSM7245955 t1982,cerebellum,dup-wt
- GSM7245956 T1982,cortex,dup-wt
- GSM7245957 t1982,striatum,dup-wt
- GSM7245958 t1983,cerebellum,dup
- GSM7245959 T1983,cortex,dup
- GSM7245960 t1983,striatum,dup
- GSM7245961 t1984,cerebellum,dup
- GSM7245962 T1984,cortex,dup
- GSM7245963 t1984,striatum,dup
- GSM7245964 t1985,cerebellum,dup
- GSM7245965 T1985,cortex,dup
- GSM7245966 t1985,striatum,dup
- GSM7245967 t1986,cerebellum,dup
- GSM7245968 T1986,cortex,dup
- GSM7245969 t1986,striatum,dup
- GSM7245970 t1987,cerebellum,del-wt
- GSM7245971 T1987,cortex,del-wt
- GSM7245972 t1987,striatum,del-wt
- GSM7245973 t1988,cerebellum,del-wt
- GSM7245974 T1988,cortex,del-wt
- GSM7245975 t1988,striatum,del-wt
- GSM7245976 t1989,cerebellum,del-wt
- GSM7245977 T1989,cortex,del-wt
- GSM7245978 t1989,striatum,del-wt
- GSM7245979 t1990,cerebellum,del-wt
- GSM7245980 T1990,cortex,del-wt
- GSM7245981 t1990,striatum,del-wt
- GSM7245982 t1991,cerebellum,del
- GSM7245983 T1991,cortex,del
- GSM7245984 t1991,striatum,del
- GSM7245985 t1992,cerebellum,del
+ 24 more — browse all 64 samples with per-sample file links →
- GSE339197 Transcription-dependent heterochromatin at the Xist promoter shapes the random choice of the inactive X chromosome [Regulators_KD_CutnTag] 44 samples shares chromosome, regulator
- GSE319614 Bulk RNA-seq transcriptome profiling of hippocampus across 17 autism spectrum disorder mouse models 269 samples shares hippocampus
- GSE284500 Transcriptional profiling of hippocampus from a zQ175 KI mouse model of Huntington's disease treated with either HTT-10150 siRNA targeting full-length HTT or combination of HTT-634 and HTT-486 siRNAs targeting HTT1a 192 samples shares hippocampus
- GSE292224 Distinct molecular mechanisms of stress habituation in the mouse hippocampus [bulk RNA-seq] 190 samples shares hippocampus
- GSE306583 Developmental trajectory of the mouse transcriptome following placental allopregnanolone insufficiency in the somatosensosry cortex, hippocampus and cerebellum 175 samples shares hippocampus
- GSE274689 Aging promotes reactivation of the Barr body at distal chromosome regions [RNA organs] 141 samples shares chromosome
- GSE274100 Systematic identification of Y-chromosome gene functions in mouse spermatogenesis [bulk] 120 samples shares chromosome
- GSE330309 Impact of Sex Chromosomes and Gonad Type in Stress Susceptibility in Corticostriatal Brain Regions 96 samples shares chromosome
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.