Distinct molecular mechanisms of stress habituation in the mouse hippocampus [bulk RNA-seq]
Single-cell RNA-seq · mouse · 190 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 190 samples: 24 conditions, mostly with about 8 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Distinct mechanisms of transcriptomic habituation to repeated stress in the mouse hippocampusNature communications · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE292224_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1237611 and SRA study SRP571299. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 190 samples.
How we read this: 24 replicated groups read from 190 sample titles; they account for 190 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8853405 Handling_1h30min_CRS1_v1 Handling_1h30min_CRS1_v
- GSM8853406 Handling_3h_CRS1_v10 Handling_3h_CRS1_v
- GSM8853407 Handling_0min_CRS1_v11 Handling_0min_CRS1_v
- GSM8853408 Handling_24h_CRS1_v12 Handling_24h_CRS1_v
- GSM8853409 Handling_0min_CRS1_v13 Handling_0min_CRS1_v
- GSM8853410 Handling_1h30min_CRS1_v14 Handling_1h30min_CRS1_v
- GSM8853411 Handling_24h_CRS1_v15 Handling_24h_CRS1_v
- GSM8853412 Handling_24h_CRS1_v16 Handling_24h_CRS1_v
- GSM8853413 Handling_45min_CRS1_v17 Handling_45min_CRS1_v
- GSM8853414 Handling_3h_CRS1_v18 Handling_3h_CRS1_v
- GSM8853415 Handling_5h30min_CRS1_v19 Handling_5h30min_CRS1_v
- GSM8853416 Handling_5h30min_CRS1_v2 Handling_5h30min_CRS1_v
- GSM8853417 Handling_5h30min_CRS1_v20 Handling_5h30min_CRS1_v
- GSM8853418 Handling_3h_CRS1_v21 Handling_3h_CRS1_v
- GSM8853419 Handling_45min_CRS1_v22 Handling_45min_CRS1_v
- GSM8853420 Handling_1h30min_CRS1_v23 Handling_1h30min_CRS1_v
- GSM8853421 Handling_0min_CRS1_v24 Handling_0min_CRS1_v
- GSM8853422 Handling_45min_CRS1_v25 Handling_45min_CRS1_v
- GSM8853423 Handling_3h_CRS1_v26 Handling_3h_CRS1_v
- GSM8853424 Handling_5h30min_CRS1_v27 Handling_5h30min_CRS1_v
- GSM8853425 Handling_0min_CRS1_v28 Handling_0min_CRS1_v
- GSM8853426 Handling_24h_CRS1_v29 Handling_24h_CRS1_v
- GSM8853427 Handling_3h_CRS1_v3 Handling_3h_CRS1_v
- GSM8853428 Handling_5h30min_CRS1_v30 Handling_5h30min_CRS1_v
- GSM8853429 Handling_0min_CRS1_v31 Handling_0min_CRS1_v
- GSM8853430 Handling_24h_CRS1_v32 Handling_24h_CRS1_v
- GSM8853431 Handling_1h30min_CRS1_v33 Handling_1h30min_CRS1_v
- GSM8853432 Handling_45min_CRS1_v34 Handling_45min_CRS1_v
- GSM8853433 Handling_3h_CRS1_v35 Handling_3h_CRS1_v
- GSM8853434 Handling_1h30min_CRS1_v36 Handling_1h30min_CRS1_v
- GSM8853435 Handling_3h_CRS1_v37 Handling_3h_CRS1_v
- GSM8853436 Handling_0min_CRS1_v38 Handling_0min_CRS1_v
- GSM8853437 Handling_24h_CRS1_v39 Handling_24h_CRS1_v
- GSM8853438 Handling_1h30min_CRS1_v4 Handling_1h30min_CRS1_v
- GSM8853439 Handling_45min_CRS1_v40 Handling_45min_CRS1_v
- GSM8853440 Handling_5h30min_CRS1_v41 Handling_5h30min_CRS1_v
- GSM8853441 Handling_1h30min_CRS1_v42 Handling_1h30min_CRS1_v
- GSM8853442 Handling_45min_CRS1_v43 Handling_45min_CRS1_v
- GSM8853443 Handling_24h_CRS1_v44 Handling_24h_CRS1_v
- GSM8853444 Handling_0min_CRS1_v45 Handling_0min_CRS1_v
+ 150 more — browse all 190 samples with per-sample file links →
- GSE319614 Bulk RNA-seq transcriptome profiling of hippocampus across 17 autism spectrum disorder mouse models 269 samples shares hippocampus, rna-seq, bulk
- GSE326452 Bulk RNA-seq of mouse brain following closed head injury: role of IL-1R1 signaling 200 samples shares rna-seq, bulk
- GSE228960 Bulk RNA-Seq from kidneys of uninephrectomized db/db mice as a model of severe diabetic kidney disease 28 samples shares rna-seq, bulk
- GSE330674 Glucocorticoid resistance during chronic social stress in mice: RNA-seq of prefrontal cortex 24 samples shares rna-seq, stress
- GSE303772 Ontogenically distinct alveolar macrophages mediate cigarette smoke-induced inflammation and damage [RNA-Seq] 24 samples shares distinct, rna-seq
- GSE291118 Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer [RNA-seq] 20 samples shares rna-seq, stress
- GSE271662 RNA-seq of Mouse Spinal Cord after Lateral Compression Spinal Cord Injury followed by Delayed Atorvastatin or Vehicle Treatment [Bulk RNA-seq of mice spinal cords] 16 samples shares rna-seq, bulk
- GSE273440 A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies [scRNA-seq] 13 samples shares distinct, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.