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The glucocorticoid receptor potentiates aldosterone-induced transcription by the mineralocorticoid receptor

GSE232089 Mus musculus (mouse) ChIP-seq / ATAC-seq (genome binding and open chromatin) 77 samples Submitted 2024/11/01 Platform GPL19057Platform GPL24247
At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 77 samples

What it is
ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism
Mus musculus (mouse)
Samples
77 samples: 18 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
The glucocorticoid receptor potentiates aldosterone-induced transcription by the mineralocorticoid receptorProceedings of the National Academy of Sciences of the United States of America · 2024
Summary (written by the submitters)
We show that GR co-expression alters MR genome-wide binding and transcriptional activity in a locus and ligand specific way.
Published in
The glucocorticoid receptor potentiates aldosterone-induced transcription by the mineralocorticoid receptor
Johnson TA, Fettweis G, Wagh K et al. · Proceedings of the National Academy of Sciences of the United States of America 2024 · PMID 39541347 · doi:10.1073/pnas.2413737121
This dataset
Open GSE232089 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE232089_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA970797 and SRA study SRP436702. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 39541347) ↗
Study design
18 conditions, mostly in triplicate
WT_Mouse_Colon_IEC_Organoid Total_RNA-Seq; 2 … ×6 WT_Mouse_Colon_IEC_Organoid Total_RNA-Seq; 2 … ×6 GRKO_Mouse_Colon_IEC_Organoid Total_RNA-Seq; … ×5 GRKO_Mouse_Colon_IEC_Organoid Total_RNA-Seq; … ×5 GRKO_MR-2B12_NT_RNA ×3 GRKO_MR-2B12_Ald_RNA ×3 GRKO_MR-2B12_Ct_RNA ×3 Parental_MR-1G12_NT_RNA ×3 +24 more

Supports a case/control comparison: 7 samples read as cases, 28 as controls.

How we read this: 18 replicated groups read from 77 sample titles; they account for 63 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 37 more — browse all 77 samples with per-sample file links →

Datasets on a similar topic

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.