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E14 cells knockdown with shRNA

GSE232524 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/08/28 Platform GPL28457
Summary
Transcription factors are considered to be the master switches that determine the state and fate of cells. Sox2 is an important transcription factor necessary for the pluripotency and self-renewal of embryonic stem cells. Sox2 is generally considered to play a role in the initiation of transcription, but recent studies have shown that Sox2 may influence the alternative splicing of pluripotent genes with the assistance of proteins associated with RNA metabolism, suggesting that Sox2 may be regulated in a novel way during the maintenance of pluripotency in embryonic stem cells. Using mouse embryonic stem cell model, this project focused on Sox2 and proteins related to RNA metabolism to explore their mode of action and the mechanism of regulating the maintenance of pluripotency of embryonic stem cells.
Published in
SOX2 interacts with hnRNPK to modulate alternative splicing in mouse embryonic stem cells
Huang Y, Liu Y, Pu M et al. · Cell & bioscience 2024 · PMID 39160617 · doi:10.1186/s13578-024-01284-8
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Direct links to NCBI, no account and no request form: the whole study as GSE232524_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA972667 and SRA study SRP437693. Searching any of these in the dataset finder brings you back here.

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