SUMOylation inhibition potentiates the glucocorticoid receptor to program growth arrest of acute lymphoblastic leukemia cells
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 36 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- Acute lymphoblastic leukemiaThis series is part of our curated briefing on it.
- Samples
- 36 samples: 16 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- SUMOylation inhibition potentiates the glucocorticoid receptor to program growth arrest of acute lymphoblastic leukemia cellsOncogene · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE233553_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA976648 and SRA study SRP439786. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 32 samples.
How we read this: 16 replicated groups read from 36 sample titles; they account for 32 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7430165 NALM6_ATAC_CTRL_rep1 NALM6_ATAC_CTRL
- GSM7430166 NALM6_ATAC_CTRL_rep2 NALM6_ATAC_CTRL
- GSM7430167 NALM6_ATAC_Dex_rep1 NALM6_ATAC_Dex
- GSM7430168 NALM6_ATAC_Dex_rep2 NALM6_ATAC_Dex
- GSM7430169 NALM6_ATAC_SUMOi_rep1 NALM6_ATAC_SUMOi
- GSM7430170 NALM6_ATAC_SUMOi_rep2 NALM6_ATAC_SUMOi
- GSM7430171 NALM6_ATAC_DexSUMOi_rep1 NALM6_ATAC_DexSUMOi
- GSM7430172 NALM6_ATAC_DexSUMOi_rep2 NALM6_ATAC_DexSUMOi
- GSM7430173 NALM6_GR_CTRL_rep1 NALM6_GR_CTRL
- GSM7430174 NALM6_GR_CTRL_rep2 NALM6_GR_CTRL
- GSM7430175 NALM6_GR_Dex_rep1 NALM6_GR_Dex
- GSM7430176 NALM6_GR_Dex_rep2 NALM6_GR_Dex
- GSM7430177 NALM6_GR_SUMOi_rep1 NALM6_GR_SUMOi
- GSM7430178 NALM6_GR_SUMOi_rep2 NALM6_GR_SUMOi
- GSM7430179 NALM6_GR_DexSUMOi_rep1 NALM6_GR_DexSUMOi
- GSM7430180 NALM6_GR_DexSUMOi_rep2 NALM6_GR_DexSUMOi
- GSM7430181 NALM6_SUMO2_CTRL_rep1 NALM6_SUMO2_CTRL
- GSM7430182 NALM6_SUMO2_CTRL_rep2 NALM6_SUMO2_CTRL
- GSM7430183 NALM6_SUMO2_Dex_rep1 NALM6_SUMO2_Dex
- GSM7430184 NALM6_SUMO2_Dex_rep2 NALM6_SUMO2_Dex
- GSM7430185 NALM6_SUMO2_SUMOi_rep1 NALM6_SUMO2_SUMOi
- GSM7430186 NALM6_SUMO2_SUMOi_rep2 NALM6_SUMO2_SUMOi
- GSM7430187 NALM6_SUMO2_DexSUMOi_rep1 NALM6_SUMO2_DexSUMOi
- GSM7430188 NALM6_SUMO2_DexSUMOi_rep2 NALM6_SUMO2_DexSUMOi
- GSM7430189 NALM6_input_CTRL_rep1
- GSM7430190 NALM6_input_Dex_rep1
- GSM7430191 NALM6_input_SUMOi_rep1
- GSM7430192 NALM6_input_DexSUMOi_rep1
- GSM7430193 NALM6_RNA_CTRL_rep1 NALM6_RNA_CTRL
- GSM7430194 NALM6_RNA_CTRL_rep2 NALM6_RNA_CTRL
- GSM7430195 NALM6_RNA_Dex_rep1 NALM6_RNA_Dex
- GSM7430196 NALM6_RNA_Dex_rep2 NALM6_RNA_Dex
- GSM7430197 NALM6_RNA_SUMOi_rep1 NALM6_RNA_SUMOi
- GSM7430198 NALM6_RNA_SUMOi_rep2 NALM6_RNA_SUMOi
- GSM7430199 NALM6_RNA_DexSUMOi_rep1 NALM6_RNA_DexSUMOi
- GSM7430200 NALM6_RNA_DexSUMOi_rep2 NALM6_RNA_DexSUMOi
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.