Memory-like natural killer cell and CD19-antibody based immunotherapy in combination with tyrosine-kinase inhibition of Ph(-like) acute lymphoblastic leukemia
DNA methylation · human · 28 samples
- What it is
- DNA methylationChemical marks on DNA that help switch genes on or off.
- Organism
- Homo sapiens (human)
- Topic
- Acute lymphoblastic leukemiaThis series is part of our curated briefing on it.
- Samples
- 28 samples: 26 distinct titles, 2 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed expression table (series matrix) and the array files, from NCBI.
- Paper
- Memory-like Natural Killer Cell and CD19 Antibody-Based Immunotherapy in Combination with Tyrosine Kinase Inhibition Has Antitumor Effects against Ph(-like) Acute Lymphoblastic LeukemiaCancer immunology research · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE268066_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.
Also filed as BioProject PRJNA1114114 and SRA study SRP509068. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 2 samples read as cases, 13 as controls.
How we read this: Read from 28 sample titles: 26 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8285255 D25, K562-expanded, control
- GSM8285256 D25, K562-expanded, preactivated
- GSM8285257 D48, K562-expanded, control
- GSM8285258 D48, K562-expanded, preactivated
- GSM8285259 D50, K562-expanded, control
- GSM8285260 D50, K562-expanded, preactivated
- GSM8285261 D41, mag-iso, control
- GSM8285262 D41, mag-iso, preactivated
- GSM8285263 D43, mag-iso, control
- GSM8285264 D43, mag-iso, preactivated
- GSM8285265 D48, mag-iso, preactivated
- GSM8285266 immune, healthy
- GSM8285267 immune, patient1
- GSM8285268 immune, patient2
- GSM8285269 D01, mag-iso, control
- GSM8285270 D01, mag-iso, pre-activated
- GSM8285271 D02, mag-iso, control
- GSM8285272 D02, mag-iso, pre-activated
- GSM8285273 D03, mag-iso, control
- GSM8285274 D03, mag-iso, pre-activated
- GSM8285275 D20, K562-expanded, control
- GSM8285276 D20, K562-expanded, pre-activated
- GSM8285277 D25, K562-expanded, control
- GSM8285278 D25, K562-expanded, pre-activated
- GSM8285279 D34, K562-expanded, control
- GSM8285280 D34, K562-expanded, pre-activated
- GSM8285281 D37, K562-expanded, control
- GSM8285282 D37, K562-expanded, pre-activated
- GSE12995 Expression data for diagnosis acute lymphoblastic leukemia samples 175 samples same disease briefing · shares lymphoblastic, leukemia
- GSE160298 The chromatin accessibility landscape of T-Cell Acute Lymphoblastic Leukemia 80 samples same disease briefing · shares lymphoblastic, leukemia
- GSE115656 Alternative splicing analysis of pediatric B-cell acute lymphoblastic leukemia compared to normal bone marrow derived pro-B cells 38 samples same disease briefing · shares lymphoblastic, leukemia
- GSE13425 Expression data from ALL patients included in the set used to construct a classification signature (COALL cohort) 190 samples same disease briefing
- GSE154675 PHF6 Interacts with LMO2 During Normal Haematopoiesis and in Leukaemia and Regulates the Level of Gene Expression and Genome Integrity 41 samples same disease briefing
- GSE193713 Genome-wide maps of chromatin state for histone modifications and chromatin remodeling factors in WT and PHF6-KO conditions in Jurkat T-ALL cells. 20 samples same disease briefing
- GSE18198 Expression profile of human T-ALL cell lines treated with DMSO or SAHM1 12 samples same disease briefing
- GSE243299 3D Chromatin Remodeling in B-cell Development and B-cell Acute Lymphoblastic Leukemia 112 samples shares lymphoblastic, leukemia
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.