GEO series
Effect of RNF4 depletion on GSK3685032-induced chromatin accessibilty changes in MV4-11 cells [ATAC-seq]
GSE233725
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
11 samples
2026/05/17
GPL24676
Summary
GSK3685032-induced DNA hypomethylation results in upregulation of largely viral-responsive gene expression pathways and cell death. We identified that loss of RNF4 causes resistance to GSK3685032. We established RNF4 wild type and deficient MV4-11 cells by CRISPR-Cas9 disruption and treated with vehicle or GSK3685032 to determine how RNF4-deficiency impacts GSK3685032-induced gene expression changes
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