RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function
RNA-seq (gene expression) · human · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 24 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell functionDiabetologia · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE234289_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA980693 and SRA study SRP441395. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 24 more — browse all 24 samples with per-sample file links →
- GSE283452 HUMAN ALVEOLAR MACROPHAGE FUNCTION IS IMPAIRED IN TUBERCULOSIS CONTACTS WITH DIABETES 89 samples shares diabetes, impaired
- GSE337220 Impaired mechanotransduction in second heart field-derived smooth muscle cells causes NOTCH1 haploinsufficiency-associated aortopathy 18 samples shares haploinsufficiency, impaired
- GSE278756 Viral triggers of Type 1 diabetes: Effects of Coxsackie B virus infection on transcriptome of trophoblast and pancreatic beta cell lines. 15 samples shares diabetes, beta
- GSE245474 RFX6 Regulates Human Intestinal Patterning and Function Upstream of PDX1 55 samples shares rfx6
- GSE81608 RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes 1600 samples shares diabetes
- GSE86473 Single cell transcriptomics defines human islet cell signatures and reveals cell-type-specific expression changes in type 2 diabetes 662 samples shares diabetes
- GSE86469 Single cell transcriptomics defines human islet cell signatures and reveals cell-type-specific expression changes in type 2 diabetes [single cell] 638 samples shares diabetes
- GSE249997 Liver dysfunction in obesity is associated with cerebrovascular health independently of diabetes and hypertension. 77 samples shares diabetes
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.