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RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes

GSE81608 Homo sapiens Expression profiling by high throughput sequencing 1600 samples Submitted 2016/08/31 Platform GPL16791
Summary
Pancreatic islet cells are critical for maintaining normal blood glucose levels and their malfunction underlies diabetes development and progression. We used single-cell RNA sequencing to determine the transcriptomes of 1,492 human pancreatic α-, β-, δ- and PP cells from non-diabetic and type 2 diabetes organ donors. We identified cell type specific genes and pathways as well as 245 genes with disturbed expression in type 2 diabetes. Importantly, 92% of the genes have not previously been associated with islet cell function or growth. Comparison of gene profiles in mouse and human α- and β-cells revealed species-specific expression. All data are available for online browsing and download and will hopefully serve as a resource for the islet research community.
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Also filed as BioProject PRJNA322072 and SRA study SRP075377. Searching any of these in the dataset finder brings you back here.

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