GGNBP2 regulates MDA5 sensing triggered by self double stranded RNA following loss of ADAR1 editing
RNA-seq (gene expression) · mouse · 95 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 95 samples: 78 distinct titles, 12 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editingScience immunology · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE234570_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA982066 and SRA study SRP439554. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 95 sample titles: 78 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7428263 sgCTRL_nuclear_d1_rep1_CW_19
- GSM7428264 sgCTRL_cyto_d1_rep1_CW_37
- GSM7428265 sgCTRL_total_d1_rep1_CW_1
- GSM7428266 sgCTRL_nuclear_d1_rep2_CW_20
- GSM7428267 sgCTRL_cyto_d1_rep2_CW_38
- GSM7428268 sgCTRL_total_d1_rep2_CW_2
- GSM7428269 sgCTRL_nuclear_d1_rep3_CW_21
- GSM7428270 sgCTRL_cyto_d1_rep3_CW_39
- GSM7428271 sgCTRL_total_d1_rep3_CW_3
- GSM7428272 sgCTRL_nuclear_d3_rep1_CW_28
- GSM7428273 sgCTRL_cyto_d3_rep1_CW_46
- GSM7428274 sgCTRL_total_d3_rep1_CW_10
- GSM7428275 sgCTRL_nuclear_d3_rep2_CW_29
- GSM7428276 sgCTRL_cyto_d3_rep2_CW_47
- GSM7428277 sgCTRL_total_d3_rep2_CW_11
- GSM7428278 sgCTRL_nuclear_d3_rep3_CW_30
- GSM7428279 sgCTRL_cyto_d3_rep3_CW_48
- GSM7428280 sgCTRL_total_d3_rep3_CW_12
- GSM7428281 sgMDA5_nuclear_d1_rep1_CW_25
- GSM7428282 sgMDA5_cyto_d1_rep1_CW_43
- GSM7428283 sgMDA5_total_d1_rep1_CW_7
- GSM7428284 sgMDA5_nuclear_d1_rep2_CW_26
- GSM7428285 sgMDA5_cyto_d1_rep2_CW_44
- GSM7428286 sgMDA5_total_d1_rep2_CW_8
- GSM7428287 sgMDA5_nuclear_d1_rep3_CW_27
- GSM7428288 sgMDA5_cyto_d1_rep3_CW_45
- GSM7428289 sgMDA5_total_d1_rep3_CW_9
- GSM7428290 sgMDA5_nuclear_d3_rep1_CW_34
- GSM7428291 sgMDA5_cyto_d3_rep1_CW_52
- GSM7428292 sgMDA5_total_d3_rep1_CW_16
- GSM7428293 sgMDA5_nuclear_d3_rep2_CW_35
- GSM7428294 sgMDA5_cyto_d3_rep2_CW_53
- GSM7428295 sgMDA5_total_d3_rep2_CW_17
- GSM7428296 sgMDA5_nuclear_d3_rep3_CW_36
- GSM7428297 sgMDA5_cyto_d3_rep3_CW_54
- GSM7428298 sgMDA5_total_d3_rep3_CW_18
- GSM7428299 sgGgnbp2_nuclear_d1_rep1_CW_22
- GSM7428300 sgGgnbp2_cyto_d1_rep1_CW_40
- GSM7428301 sgGgnbp2_total_d1_rep1_CW_4
- GSM7428302 sgGgnbp2_nuclear_d1_rep2_CW_23
+ 55 more — browse all 95 samples with per-sample file links →
- GSE233452 Fractionation of sgControl, sgIfih1 and sgGgnbp2 in HoxA9 immortalized Rosa26-CreERT2 Adar1fl/E861A immortalised myeloid cells. 54 samples shares ggnbp2, adar1
- GSE280641 Effect of conditional SMC specific deletion of ADAR1 with constitutive deletion of RNA sensor MDA5 on mouse aortic single cell transcriptomic profile and effect on atherosclerosis 12 samples shares adar1, mda5
- GSE233934 Ggnbp2 and Ifih1 knockout in HoxA9 immortalised R26-CreERT2 Adar1fl/E861A myeliod cell line. 7 samples shares ggnbp2, adar1
- GSE233991 Ggnbp2 knockout in HoxA9 immortalised R26-CreERT2 Adar1fl/+ myeliod cell line. 6 samples shares ggnbp2, adar1
- GSE87068 RNA Sequencing Quantitative Analysis of RNA editing sites of Wild Type and ADAR1 editing deficient (ADAR1E861A) murine fetal RNA of various tissues 43 samples shares adar1, editing
- GSE281540 Adenosine to Inosine RNA editing level in mouse lungs from Adar1 K999N mutants or hypoxia-exposed mice 9 samples shares adar1, editing
- GSE58917 RNA Sequencing Quantitative Analysis and identification of RNA editing sites of Wild Type and ADAR1 editing deficient (ADAR1E861A) murine fetal liver RNA 6 samples shares adar1, editing
- GSE283569 Targeting ADAR1-mediated RNA editing inhibits hepatic stellate cell activation and liver fibrosis by enhancing HSC-intrinsic IFN signaling 2 samples shares adar1, editing
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.