GEO series
Splicing targeting approaches highlight actionable vulnerabilities in advanced prostate cancer [22Rv1]
GSE234734
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2024/03/06
GPL24676
Summary
To investigate if pharmacological inhibition of splicing could uncover novel actionable vulnerabilities in CRPC, we profiled the genome-wide transcriptional changes elicited in 22Rv1 cells by treatment with three drugs that inhibit the splicing through different molecular targets: i. Pladienolide B, that impairs the activity of SF3B1; ii. Indisulam that promote degradation of the splicing factor RBM39; iii. THZ531 inhibits the cyclin dependent kinases (CDK) 12 and 13.
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Paper (PMID 38413979) ↗
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