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Differential chromatin landscape in myxoid liposarcoma and Ewing sarcoma

GSE235218 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2025/09/22 Platform GPL24676
Summary
A subgroup of sarcomas and leukemias is defined by characteristic FET (FUS, EWSR1, TAF15) fusion oncogenes. Myxoid liposarcoma (MLS) and Ewing sarcoma (EWS) are the most common entities characterized by the fusion oncogenes FUS-DDIT3 and EWSR1-FLI1, respectively. Here, we performed ATAC-Seq on the cell lines MLS 1765-92 and EWS TC-71 to characterize and compare their chromatin landscape.
Published in
FET fusion oncoproteins enrich SWI/SNF complex subtypes and interaction partners
Lindén M, Andersson L, Albatrok H et al. · Cellular & molecular biology letters 2025 · PMID 40988026 · doi:10.1186/s11658-025-00792-w
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Direct links to NCBI, no account and no request form: the whole study as GSE235218_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA985567 and SRA study SRP444848. Searching any of these in the dataset finder brings you back here.

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