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Aging- and Alcohol-Associated Spatial Transcriptomic Signature in Mouse Acute Pancreatitis

GSE235247 Mus musculus Expression profiling by high throughput sequencing; Other 4 samples Submitted 2024/08/02 Platform GPL24247
Summary
The rapidly aging population has an increased alcohol use, resulting in increased risk and mortality of alcohol-associated acute pancreatitis in the elderly population. We established an aging- and alcohol-associated acute pancreatitis mouse model and applied spatial transcriptomics to profile heterogenous tissue composition in the mouse pancreas and the associated gene expression. By comparing with the young cohorts, our analysis has revealed the key differentially expressed genes in functional tissue compartments for understanding the mechanisms and developing targeted therapeutic strategies.
Published in
Aging- and alcohol-associated spatial transcriptomic signature in mouse acute pancreatitis reveals heterogeneity of inflammation and potential pathogenic factors
Tindall RR, Yang Y, Hernandez I et al. · Journal of molecular medicine (Berlin, Germany) 2024 · PMID 38940937 · doi:10.1007/s00109-024-02460-6
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Also filed as BioProject PRJNA985604 and SRA study SRP444824. Searching any of these in the dataset finder brings you back here.

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