Dietary tyramine promotes colon cancer risk and development via increased DNA damage and enhanced Inflammation
RNA-seq (gene expression) · human · 87 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Colorectal cancerThis series is part of our curated briefing on it.
- Samples
- 87 samples: 72 distinct titles, 3 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Roux-en-Y gastric bypass-associated fecal tyramine promotes colon cancer risk via increased DNA damage, cell proliferation, and inflammationMicrobiome · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE235266_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA985629 and SRA study SRP440640. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 12 samples read as cases, 57 as controls.
How we read this: Read from 87 sample titles: 72 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7438379 HCT116, untreated, biol rep1
- GSM7438380 HCT116, untreated, biol rep2
- GSM7438381 HCT116, untreated, biol rep3
- GSM7438382 HCT116, untreated, biol rep4
- GSM7438383 HCT116, untreated, biol rep5
- GSM7438384 HCT116, untreated, biol rep6
- GSM7438385 HCT116, tyramine treatment, 1.2mM, biol rep1
- GSM7438386 HCT116, tyramine treatment, 1.2mM, biol rep2
- GSM7438387 HCT116, tyramine treatment, 1.2mM, biol rep3
- GSM7438388 HCT116, tyramine treatment, 1.2mM, biol rep4
- GSM7438389 HCT116, tyramine treatment, 1.2mM, biol rep5
- GSM7438390 HCT116, tyramine treatment, 1.2mM, biol rep6
- GSM7438391 HCT116, tyramine treatment, 1.6mM, biol rep1
- GSM7438392 HCT116, tyramine treatment, 1.6mM, biol rep2
- GSM7438393 HCT116, tyramine treatment, 1.6mM, biol rep3
- GSM7438394 HCT116, tyramine treatment, 1.6mM, biol rep4
- GSM7438395 HCT116, tyramine treatment, 1.6mM, biol rep5
- GSM7438396 HCT116, tyramine treatment, 1.6mM, biol rep6
- GSM7498000 APC_699, APCmin/+, water, ileum, tumour
- GSM7498001 APC_700, APCmin/+, tyramine, ileum, tumour
- GSM7498002 APC_706, APCmin/+, tyramine, ileum, tumour
- GSM7498003 APC_713, APCmin/+, water, ileum, tumour
- GSM7498004 APC_718, APCmin/+, tyramine, ileum, tumour
- GSM7498005 APC_853, APCmin/+, water, ileum, tumour
- GSM7498006 APC_856, APCmin/+, tyramine, ileum, tumour
- GSM7498007 APC_858, APCmin/+, water, ileum, tumour
- GSM7498008 APC_860, APCmin/+, tyramine, ileum, tumour
- GSM7498009 APC_864, APCmin/+, tyramine, ileum, tumour
- GSM7498010 APC_865, APCmin/+, water, ileum, tumour
- GSM7498011 APC_866, APCmin/+, water, ileum, tumour
- GSM7498012 APC_699, APCmin/+, water, ileum, healthy
- GSM7498013 APC_700, APCmin/+, tyramine, ileum, healthy
- GSM7498014 APC_701, APCmin/+, water, ileum, healthy
- GSM7498015 APC_702, wt, tyramine, ileum, healthy
- GSM7498016 APC_704, APCmin/+, water, ileum, healthy
- GSM7498017 APC_705, wt, water, ileum, healthy
- GSM7498018 APC_706, APCmin/+, tyramine, ileum, healthy
- GSM7498019 APC_708, wt, water, ileum, healthy
- GSM7498020 APC_709, APCmin/+, water, ileum, healthy
- GSM7498021 APC_710, wt, tyramine, ileum, healthy
+ 47 more — browse all 87 samples with per-sample file links →
- GSE110009 Single cell transcriptome landscape of primary and metastatic tumor in colon cancer 76 samples same disease briefing · shares colon
- GSE250000 Bulk RNA-sequencing of transduced colorectal cancer cell line HCT-116 and breast cancer cell line MCF-7 overexpressing full-lenght p53β or p53β-stop-lost. 4 samples same disease briefing
- GSE12032 Inherent gene signature of stage II and III colorectal cancer leads in individual recurrence 198 samples same disease briefing
- GSE109308 Single-cell transcriptomic survey of adenomatous polyposis patients with germline APC mutations 97 samples same disease briefing
- GSE278785 Obesity facilitated colon cancer progression is mediated by increased diacylglycerol o-acyltransferases 1 and 2 (DGAT1/2) levels [RNA-seq] 26 samples shares increased, colon
- GSE290037 Loss of IL13RA2 promotes metastatic tumour growth in triple-negative breast cancer via increased AKT signalling 21 samples shares increased, promotes
- GSE250614 Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst 225 samples shares promotes
- GSE279626 PGLYRP-1 mediated intracellular peptidoglycan detection promotes mucosal protection 82 samples shares promotes
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.