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Rebalancing the brain: The therapeutic potential of false neurotransmitters in excitatory-inhibitory imbalance

GSE235285 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/04/01 Platform GPL24247
Summary
Excitatory-inhibitory (E-I) balance results from a complex interplay between glutamatergic and GABAergic neurons, and E-I imbalance has been proposed to contribute to many neurological diseases. We have created the first excitatory (S-2-methyglutamate or S-2MeGlu) and inhibitory (R-4-aminopentanoate or R-4APA) false neurotransmitters, and using single nucleus RNA sequencing, we have tested their transcriptomic impact in wild-type mice following chronic exposure to the lowest dose
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Direct links to NCBI, no account and no request form: the whole study as GSE235285_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA985658 and SRA study SRP445018. Searching any of these in the dataset finder brings you back here.

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