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Differential genome-wide profile of RBPJ, H3K4me1 and H3K4me3 as well as differential chromatin accessibility upon treatment with gamma-secretase inibithor (GSI) DAPT (ATAC-Seq).

GSE235977 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2024/03/24 Platform GPL19057
Summary
The Notch signaling pathway regulates several processes including development and differentiation and its aberrant regulation leads to several diseases. Here, we investigated the differential chromatin accessibility, genome-wide distribution of the transcription factor RBPJ and the differential regulation of H3K4me1 and H3K4me3 upon pharmacological inhibition of the Notch pathway with gamma-secretase inibibitor (GSI) DAPT in mouse pre-T (Beko) cells.
Published in
Comprehensive genomic features indicative for Notch responsiveness
Giaimo BD, Friedrich T, Ferrante F et al. · Nucleic acids research 2024 · PMID 38647081 · doi:10.1093/nar/gkae292
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Also filed as BioProject PRJNA988123 and SRA study SRP446156. Searching any of these in the dataset finder brings you back here.

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