TLR2 in γδ T cells is required for metabolic support of IL-17A ocular mucosal immune response to a commensal bacterium
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 19 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 19 samples: 8 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- TLR2 Supports γδ T cell IL-17A Response to ocular surface commensals by Metabolic ReprogrammingbioRxiv : the preprint server for biology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE236387_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA990716 and SRA study SRP447133. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 2 samples read as cases, 2 as controls.
How we read this: 8 replicated groups read from 19 sample titles; they account for 19 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7528927 TLR2-deficient mice, C. mast inoculated, rep1 TLR2-deficient mice, C.…
- GSM7528928 TLR2-deficient mice, C. mast inoculated, rep2 TLR2-deficient mice, C.…
- GSM7528929 TLR2-deficient mice, PBS treated, rep1 TLR2-deficient mice, PB…
- GSM7528930 TLR2-deficient mice, PBS treated, rep2 TLR2-deficient mice, PB…
- GSM7528931 WT mice, C. mast inoculated, rep1 WT mice, C. mast inocul…
- GSM7528932 WT mice, C. mast inoculated, rep2 WT mice, C. mast inocul…
- GSM7528933 WT mice, PBS treated, rep1 WT mice, PBS treated,
- GSM7528934 WT mice, PBS treated, rep2 WT mice, PBS treated,
- GSM7529010 RNA-seq_TLR2-deficient mice, naïve, rep1 RNA-seq_TLR2-deficient …
- GSM7529011 RNA-seq_TLR2-deficient mice, naïve, rep2 RNA-seq_TLR2-deficient …
- GSM7529012 RNA-seq_WT mice, naïve, rep1 RNA-seq_WT mice, naïve,
- GSM7529013 RNA-seq_WT mice, naïve, rep2 RNA-seq_WT mice, naïve,
- GSM7529014 RNA-seq_WT mice, naïve, rep3 RNA-seq_WT mice, naïve,
- GSM7529015 RNA-seq_TLR2-deficient mice, C. mast inoculated, rep1 RNA-seq_TLR2-deficient …
- GSM7529016 RNA-seq_TLR2-deficient mice, C. mast inoculated, rep2 RNA-seq_TLR2-deficient …
- GSM7529017 RNA-seq_TLR2-deficient mice, C. mast inoculated, rep3 RNA-seq_TLR2-deficient …
- GSM7529018 RNA-seq_WT mice, C. mast inoculated, rep1 RNA-seq_WT mice, C. mas…
- GSM7529019 RNA-seq_WT mice, C. mast inoculated, rep2 RNA-seq_WT mice, C. mas…
- GSM7529020 RNA-seq_WT mice, C. mast inoculated, rep3 RNA-seq_WT mice, C. mas…
- GSE236386 TLR2 in γδ T cells is required for metabolic support of IL-17A ocular mucosal immune response to a commensal bacterium [RNA-seq] 11 samples shares il-17a, tlr2, commensal, bacterium, required, support, mucosal, ocular
- GSE320380 Competition between commensal protists shapes gut mucosal immunity in mice 59 samples shares commensal, mucosal
- GSE326266 Commensal-derived acetylcholine enhances mucosal immune education [mouse_lamina_propria_bulk_RNA-seq] 16 samples shares commensal, mucosal
- GSE326264 Commensal-derived acetylcholine enhances mucosal immune education [mouse_ileum_lamina_propria_scRNA-seq] 2 samples shares commensal, mucosal
- GSE75111 Single-cell transcriptional profiling of Th17 cells, differentiated in vitro for 48h [TGFB1_IL6-48h-IL-17A/GFP+] 151 samples shares il-17a
- GSE75109 Single-cell transcriptional profiling of Th17 cells, differentiated in vitro for 48h [IL1B_IL6_IL23-48h-IL-17A/GFP+] 139 samples shares il-17a
- GSE226344 Primary lung fibroblasts respond to IL-33, IL-13, and IL-17a and secrete factors that activate macrophages 39 samples shares il-17a
- GSE226343 Primary lung fibroblasts respond to IL-33, IL-13, and IL-17a and secrete factors that activate macrophages [JV214] 24 samples shares il-17a
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.