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Inflammatory Alterations to Renal Lymphatic Endothelial Cell Gene Expression in Mouse Models of Hypertension

GSE236410 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/05/14 Platform GPL24247
Summary
To evaluate the specific changes that renal LECs undergo in hypertension (HTN), we performed single-cell RNA sequencing. Using the angiotensin II-induced and salt-sensitive mouse models of HTN, we isolated renal CD31+ and podoplanin+ cells from hypertensive and normotensive mice. Sequencing of these cells revealed three distinct cell types (LECs, myeloid immune cells, and an unusual third population we dubbed multipotent nephron-associated support cells) with unique expression profiles.
Published in
Inflammatory Alterations to Renal Lymphatic Endothelial Cell Gene Expression in Mouse Models of Hypertension
McDermott JG, Goodlett BL, Creed HA et al. · Kidney & blood pressure research 2024 · PMID 38972305 · doi:10.1159/000539721
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Also filed as BioProject PRJNA990767 and SRA study SRP447185. Searching any of these in the dataset finder brings you back here.

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