← BioTransfer GEO Dataset Finder
GEO series

Combined analysis of metabolomics, proteomics, and transcriptomics to identify biomarkers for resistant hypertension

GSE236442 Homo sapiens (human) RNA-seq (gene expression) 30 samples Submitted 2025/02/05 Platform GPL24676
At a glance

RNA-seq (gene expression) · human · 30 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Homo sapiens (human)
Samples
30 samples: 10 × N vs 10 × EH vs 10 × RHGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Joint Analysis of Multiple Omics to Describe the Biological Characteristics of Resistant HypertensionJournal of clinical hypertension (Greenwich, Conn.) · 2025
Summary (written by the submitters)
Resistant hypertension (RH) has emerged as a formidable challenge in the realm of hypertension prevention and treatment, owing to its potential for causing severe target organ damage. The identification of biomarkers assumes paramount significance in unraveling the pathogenesis of RH and facilitating early diagnosis and treatment. Despite the conduct of several single omics studies on RH, the intricate pathogenesis of this condition remains only partially understood.
Read the full summary ↓
In this study, we comprehensively analyzed metabolomics, proteomics, and transcriptomics on healthy individuals, hypertensive patients, and those with RH. A variety of substances were screened, as potential diagnostic markers for RH. The hypoxia-inducible factor-1 (HIF-1) signaling pathway was identified as the pathogenic signaling pathway for RH. In conclusion, this study provides multi-omics analysis information to enhance our understanding of the pathogenesis of RH and to explore potential diagnostic markers, providing new insights for the search for effective therapeutic targets.
Published in
Joint Analysis of Multiple Omics to Describe the Biological Characteristics of Resistant Hypertension
Wang S, Hu Y, Wang Y et al. · Journal of clinical hypertension (Greenwich, Conn.) 2025 · PMID 39716980 · doi:10.1111/jch.14961
This dataset
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE236442_RAW.tar (it can run to tens of gigabytes).

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA990810 and SRA study SRP447196. Searching any of these in the dataset finder brings you back here.

Study design
10 × N vs 10 × EH vs 10 × RH

Supports a between-group comparison across 30 samples.

How we read this: 3 replicated groups read from 30 sample titles; they account for 30 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.