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Transcriptional profiles of Tead1/4 Knockout and Unedited CT26 Cells

GSE236855 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/12/31 Platform GPL24247
Summary
The Hippo kinase cascade converges on the transcriptional effectors YAP (Yes-associated protein) and TAZ (transcriptional co-activator with PDZ-binding motif), which regulate gene expression programs by interacting with the transcriptional enhanced associate domain (TEAD) family of transcription factors (TFs). As a key pathway in organ growth, tissue homeostasis, and regeneration, the YAP/TAZ-TEAD complex controls the transcription of genes crucial for replication, S-phase entry, and mitosis. To further elucidate the transcriptional regulatory network, we monitored the target genes of TEAD1 and TEAD4 using CUT&Tag and transcriptome sequencing.
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Direct links to NCBI, no account and no request form: the whole study as GSE236855_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA992524 and SRA study SRP448142. Searching any of these in the dataset finder brings you back here.

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