GEO series
Detection of occurrent somatic hypermutation and associated gene expression profile in single B cells
GSE236880
Homo sapiens
Expression profiling by high throughput sequencing; Other
20 samples
2024/12/25
GPL20301
Summary
This study provided new insights into the molecular mechanisms of SHM. For the first time, SHM was detected at the single-cell level in 58% of FL samples but not in chronic lymphocytic leukemia (CLL) used as control. The occurrence of SHM at the single-cell level was correlated with higher expression of DNA repair pathways and activation-induced cytidine deaminase (AID), as well as the motifs associated with AID. FL is an essential in vivo model for studying SHM due to its high rate of ongoing SHM, and the findings of this study contribute to our understanding of the molecular mechanisms involved in human B-cells.
Download
NCBI GEO page ↗
{# Names what the click gives you. "Open in finder" meant nothing to a
visitor who arrived from a search engine and has never seen the tool. #}
Find more
human RNA-seq datasets →
Similar datasets
- GSE296419 The critical role of the host endogenous immune compartment after intracerebroventricular CAR T cell therapy in recurrent GBM 143 samples
- GSE335494 B-cell depletion improves therapeutic index of combination checkpoint blockade in patients with advanced melanoma 44 samples
- GSE332623 Immunological Differences in Atopic Dermatitis Across Age Groups: Insights from Single-Cell Multi-Omics 54 samples
- GSE319236 Spatially resolved maternal and fetal cell contributions to severe Preeclampsia 152 samples
- GSE317520 Mitochondrial DNA Mutations Drive Tumor Heterogeneity in Papillary Thyroid Carcinoma 92 samples
- GSE320042 High-resolution and noninvasive profiling of the tumor microenvironment with spatial ecotypes 38 samples
- GSE325670 Promoter mutagenesis and a massively parallel reporter screen of the MAPT locus identifies cis-regulatory elements and genetic variation effects 140 samples
- GSE301785 The molecular basis for fate determination of nuclear polyadenylated RNA 131 samples
Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.