Mutability and hypermutation antagonize immunoglobulin codon optimality; Analysis of human MLN B cells.
RNA-seq (gene expression) · human · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 14 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Mutability and hypermutation antagonize immunoglobulin codon optimalityMolecular cell · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE260944_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1084083 and SRA study SRP493492. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 14 more — browse all 14 samples with per-sample file links →
- GSE260943 Mutability and hypermutation antagonize immunoglobulin codon optimality; Analysis of human tonsil B cells. 6 samples shares immunoglobulin, hypermutation, mutability, antagonize, optimality, codon
- GSE202037 High-resolution transcriptional analysis of immunoglobulin variable regions reveals the absence of direct relationships between somatic hypermutation, nascent transcription and epigenetic marks [ATAC-seq] 1 samples shares immunoglobulin, hypermutation
- GSE277084 Transcriptome-based screening in TARDBP/TDP-43 knock-in motor neurons identifies the NEDD8-activating enzyme inhibitor MLN4924 [RNA-Seq] 15 samples shares mln
- GSE292171 RNA-seq of macrophages treated with or without MLN4924 5 samples shares mln
- GSE201171 Biologic characteristics of B-lymphoblastic leukemia correspond to immunoglobulin gene diversity 87 samples shares immunoglobulin
- GSE200557 Biologic characteristics of B-lymphoblastic leukemia correspond to immunoglobulin gene diversity [sequencing] 69 samples shares immunoglobulin
- GSE337533 A Single-Cell Atlas of Transcriptional and Immunoglobulin Repertoire Evolution in Early B Cell Development 66 samples shares immunoglobulin
- GSE236880 Detection of occurrent somatic hypermutation and associated gene expression profile in single B cells 20 samples shares hypermutation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.