Inflammation-dependent differentiation of two distinct regulatory T cell populations in the visceral adipose tissue shapes systemic metabolism [RNA-seq III]
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Two regulatory T cell populations in the visceral adipose tissue shape systemic metabolismNature immunology · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE237835_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA996911 and SRA study SRP450634. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 8 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7655128 Female-Dendritic-Cells-rep1 Female-Dendritic-Cells
- GSM7655129 Female-Dendritic-Cells-rep2 Female-Dendritic-Cells
- GSM7655130 Female-Macrophages-rep1 Female-Macrophages
- GSM7655131 Female-Macrophages-rep2 Female-Macrophages
- GSM7655132 Male-Dendritic-Cells-rep1 Male-Dendritic-Cells
- GSM7655133 Male-Dendritic-Cells-rep2 Male-Dendritic-Cells
- GSM7655134 Male-Macrophages-rep1 Male-Macrophages
- GSM7655135 Male-Macrophages-rep2 Male-Macrophages
- GSM7655136 Female-High-Fat-Diet-rep1 Female-High-Fat-Diet
- GSM7655137 Female-High-Fat-Diet-rep2 Female-High-Fat-Diet
- GSM7655138 Female-High-Fat-Diet-rep3 Female-High-Fat-Diet
- GSM7655139 Female-Normal-Diet-rep1 Female-Normal-Diet
- GSM7655140 Female-Normal-Diet-rep2 Female-Normal-Diet
- GSM7655141 Female-Normal-Diet-rep3 Female-Normal-Diet
- GSM7655142 Male-High-Fat-Diet-rep1 Male-High-Fat-Diet
- GSM7655143 Male-High-Fat-Diet-rep2 Male-High-Fat-Diet
- GSM7655144 Male-High-Fat-Diet-rep3 Male-High-Fat-Diet
- GSM7655145 Male-Normal-Diet-rep1 Male-Normal-Diet
- GSM7655146 Male-Normal-Diet-rep2 Male-Normal-Diet
- GSM7655147 Male-Normal-Diet-rep3 Male-Normal-Diet
- GSE274992 Splenic fibroblasts control marginal zone B-cell movement and function via two distinct Notch2-dependent regulatory programs 119 samples shares regulatory, distinct
- GSE205410 Multiple subpopulations in medullary thymic epithelial cells are regulated by Aire with distinctive modes of gene regulations [bulkRNA-seq] 47 samples shares populations, distinct
- GSE296365 Prenatal stress induces transient developmental alterations in distinct GABAergic populations and leads to long-lasting behavioral abnormalities 16 samples shares populations, distinct
- GSE274081 A distinct cis-regulatory element is required for ILC3s to maintain intestinal tolerance through amplifying RORγt expression [scRNA-seq] 2 samples shares regulatory, distinct
- GSE342312 T-bet and Runx3 orchestrate effector CD8 T cell differentiation and lineage fidelity through cooperative and distinct chromatin regulatory mechanisms [Multi-omics] 40 samples shares regulatory, distinct
- GSE233993 Determining the chromatin accessibility profiles of functionally distinct SHH-medulloblastoma sub-populations 12 samples shares populations, distinct
- GSE282257 Mitochondria complex III-generated superoxide is essential for IL-10 secretion in macrophages 40 samples shares iii
- GSE304378 Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology 27 samples shares iii
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.