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Regulatory mechanism of Sox9 gene expression in chondrocytes [ChIP-seq]

GSE237886 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 7 samples Submitted 2024/06/10 Platform GPL17021
Summary
The transcription factor Sox9 (Sry-Related HMG-Box gene 9) is essential in chondrogenesis. The expression Sox9 is regulated by 1.5Mb long range genomic region in temporospatial manner and genome translocation or deletion which affect Sox9 expression cause campomelic dysplasia (CD), characterized by skeletal malformations. Although functional mechanism of Sox9 are well studied so far, regulatory mechanism of Sox9 expression and its related enhancer in chondrocytes are largely remains to be elucidated. The purpose of this study is to identify Sox9 enhancers in chondrocytes
Published in
Chromatin profiling identifies chondrocyte-specific Sox9 enhancers important for skeletal development
Ichiyama-Kobayashi S, Hata K, Wakamori K et al. · JCI insight 2024 · PMID 38855864 · doi:10.1172/jci.insight.175486
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Direct links to NCBI, no account and no request form: the whole study as GSE237886_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 7 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA996990 and SRA study SRP450618. Searching any of these in the dataset finder brings you back here.

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