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Prominent role of gut dysbiosis in the pathogenesis of cystic fibrosis-related liver disease in mice

GSE238000 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2024/09/13 Platform GPL19057
Summary
Cystic fibrosis-related liver disease (CFLD) is a chronic cholangiopathy that increases morbidity and mortality in patients with CF. Current treatments are unsatisfactory, and incomplete understanding of CFLD pathogenesis hampers therapeutic development. We have previously shown that mouse CF cholangiocytes respond with excessive inflammation to LPS. Thus, we investigated the role of the gut-liver axis in the pathogenesis of CFLD.
Published in
Prominent role of gut dysbiosis in the pathogenesis of cystic fibrosis-related liver disease in mice
Bertolini A, Nguyen M, Zehra SA et al. · Journal of hepatology 2024 · PMID 38554847 · doi:10.1016/j.jhep.2024.03.041
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Also filed as BioProject PRJNA997360 and SRA study SRP450849. Searching any of these in the dataset finder brings you back here.

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