p53 deficient breast cancer cells reprogram pre-adipocytes towards tumor protective immunomodulatory cells
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 24 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE238232_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA998396 and SRA study SRP451346. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 24 sample titles: 24 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7660818 AD.3T3L1.4.raw (WEA)
- GSM7660819 AD.3T3L1.5.raw (WEA)
- GSM7660820 AD.3T3L1.6.raw (WEA)
- GSM7660821 AD.Regdiff.4.raw (WEA)
- GSM7660822 AD.Regdif.5.raw (WEA)
- GSM7660823 AD.Regdif.6.raw (WEA)
- GSM7660824 AD.WEA.WT.CM.1.raw
- GSM7660825 AD.WEA.WT.CM.2.raw
- GSM7660826 AD.WEA.WT.CM.3.raw
- GSM7660827 AD.WEA.KO.CM.1.raw
- GSM7660828 AD.WEA.KO.CM.2.raw
- GSM7660829 AD.WEA.KO.CM.3.raw
- GSM7660830 AD.3T3L1.1.raw
- GSM7660831 AD.3T3L1.2.raw
- GSM7660832 AD.3T3L1.3.raw
- GSM7660833 AD.Regdiff.1.raw
- GSM7660834 AD.Regdif.2.raw
- GSM7660835 AD.Regdif.3.raw
- GSM7660836 AD.WEP.WT.CM.1.raw
- GSM7660837 AD.WEP.WT.CM.2.raw
- GSM7660838 AD.WEP.WT.CM.3.raw
- GSM7660839 AD.WEP.KO.CM.1.raw
- GSM7660840 AD.WEP.KO.CM.2.raw
- GSM7660841 AD.WEP.KO.CM.3.raw
- GSE220973 Mismatch repair protein MLH1 suppresses replicative stress in BRCA2 deficient breast tumors 23 samples shares deficient, breast
- GSE98600 BCG reprogramming of hematopoietic stem cells generates protective innate immunity against tuberculosis 85 samples shares protective, reprogram
- GSE123160 Immunomodulatory properties of slowly cycling and mesenchymal-like castration-resistant prostate cancer stem cells 70 samples shares immunomodulatory
- GSE236720 Synthetic essentiality of thymine DNA glycosylase in p53-deficient cancer [RNA-seq] 26 samples shares deficient
- GSE230302 Protective effect of Pien Tze Huang on colitis-associated colorectal cancer 20 samples shares protective
- GSE236726 Synthetic essentiality of thymine DNA glycosylase in p53-deficient cancer [strand specific RNA-seq] 13 samples shares deficient
- GSE302064 Transcriptome analysis of the effect of RAD52 knockout on olaparib response in BRCA2-deficient, olaparib-resistant murine ovarian cancer cells (ID8-OR) 12 samples shares deficient
- GSE317348 Impaired removal of dying brain cells by microglia in GPR34 deficient mice 125 samples shares deficient
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.